---------------------PK NEWS----------------------------------------------
PK is an R package for inference for PK parameters in complete and
incomplete data designs based on non-compartmental methods. If you are
using the package, please cite it as
Jaki T and Wolfsegger MJ (2011) Estimation of pharmacokinetic parameters
with the R package PK. Pharmaceutical Statistics. Vol 10(No 3), 294-288.
DOI: 10.1002/pst.449"
Question or suggestions about the package can be send to
jaki.thomas@gmail.com
or
martin.wolfsegger@takeda.com
--------------------CHANGE LOG--------------------------------------------
Version 1.3-6
o Internal changes to comply with CRAN rules
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Version 1.3-5
o Internal changes to ensure compatability with newer versions of R
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Version 1.3-4
o Fixed a bug in auc.ssd, auc.batch, eqv.batch
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Version 1.3-3
o Removal of depreciated function call
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Version 1.3-2
o A bug during start-up is corrected
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Version 1.3-1
o depreciated functions as.real replaced by as.double
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Version 1.3-0
o Flexible batch designs (Jaki & Wolfsegger, Statistics in Medicine 2012)
implemented. These designs allow the same timepoints to be used in
different batches.
Functions updated: auc.batch
Help files updated: auc.batch, eqv.batch
o Methods to compute PK parameters such as Clearance in flexible
batch designs have been added in functions nca and nca.batch
o Help for nca updated
o Help for eqv.ssd, eqv.batch and eqv.complete has been merged with eqv
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Version 1.2-5
o Code in biexp and lee updated
o Several examples in help files biexp and lee added
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Version 1.2-4
o The help file for the function nca has been corrected
o Citation information updated
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Version 1.2-3
o A bug in an internal function to handle the data argument in batch
designs fixed
o Citation information updated
o A bug in the nca.complete function fixed
o A bug in the summary function fixed
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Version 1.2-2
o A repeated dose toxicity dataset included
o Help on nca function expanded
o A bug in the print function fixed
o auc.complete updated to handle individual AUCs
o Additional example in help for auc.complete included
o Function nca.complete included
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Version 1.2-1
o Default option for method lee changed to ols
o Functionality to create plots by group included
o Some formating changes in the print/summary functions
o Bug in print.PKtest fixed
o Bug in test fixed
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Version 1.2-0
o Multiple datasets included
o Bug in auc.batch fixed
o Functions can now be called using data in FDA SEND format - http://www.cdisc.org/send
o Functions est, ci and test have been included to obtain point estimates, confidence intervals and hypothesis tests
o Functions auc, eqv, nca have been aligned
o Methods to test for bioequivalence in batch designs for independent and dependent aucs have been added in functions eqv and eqv.batch
o Methods to compute PK parameters such as MRT and Clearance in serial sampling designs have been added in functions nca and nca.ssd
o Multiple references added and updated