$PROBLEM    018 with 2 comp

$INPUT ROW ID NOMTIME TIME EVID CMT AMT DV FLAG STUDY
BLQ CYCLE DOSE PART PROFDAY PROFTIME WEIGHTB eff0

$DATA     ../data/xgxr2.csv IGNORE=@ IGNORE=(FLAG.NE.0) IGNORE(DOSE.LT.30)

$SUBROUTINE ADVAN4 TRANS4

$PK
TVKA=THETA(1)
TVV2=THETA(2)
TVCL=THETA(3)
TVV3=THETA(4)
TVQ=THETA(5)
                   
KA=TVKA*EXP(ETA(1))
V2=TVV2*EXP(ETA(2))
CL=TVCL*EXP(ETA(3))
V3=TVV3*EXP(ETA(4))
Q=TVQ*EXP(ETA(5))
S2=V2

$ERROR
  IPRED=F
  IRES=DV-IPRED

  IF (IPRED.GT.1) THEN
    W = SQRT(IPRED**2*SIGMA(1,1) + SIGMA(2,2))
  ELSE
    W=1
  ENDIF

  IWRES=IRES/W
  Y=F+F*ERR(1)+ERR(2)

;-----------------------INITIAL ESTIMATES---------------------------------
$THETA  (0,1)             ; POPKA
$THETA  (0,100)             ; POPV2
$THETA  (0,3)             ; POPCL
$THETA  (0,50)             ; POPV3
$THETA  (0,.5)             ; TVQ

$OMEGA 0 FIX
$OMEGA 0.1
$OMEGA 0.1
$OMEGA 0 FIX
$OMEGA 0 FIX

$SIGMA 0.1
$SIGMA 0 FIX

$ESTIMATION METHOD=1 POSTHOC INTER MAXEVAL=9999 NSIG=2 SIGL=9
            PRINT=10 NOABORT MSFO=xgxr021.msf

$COV 

$TABLE ROW TVKA TVV2 TVV3 TVCL KA V2 V3 CL Q PRED IPRED Y NOPRINT FILE=xgxr021_res.txt
