cobenrich: Using Multiple Continuous Biomarkers for Patient Enrichment in
Two-Stage Clinical Designs
Enrichment strategies play a critical role in modern clinical trial design, especially as precision medicine advances the focus on patient-specific efficacy. Recent developments in enrichment design have introduced biomarker randomness and accounted for the correlation structure between treatment effect and biomarker, resulting in a two-stage threshold enrichment design. We propose novel two-stage enrichment designs capable of handling two or more continuous biomarkers.
See Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report.
| Version: |
1.0.1 |
| Depends: |
R (≥ 4.2.0) |
| Imports: |
tmvtnorm (≥ 1.2), stats (≥ 4.0.0) |
| Published: |
2025-04-15 |
| DOI: |
10.32614/CRAN.package.cobenrich |
| Author: |
Jiangtao Gou [aut, cre],
Fengqing (Zoe) Zhang [aut] |
| Maintainer: |
Jiangtao Gou <gouRpackage at gmail.com> |
| License: |
GPL-3 |
| NeedsCompilation: |
no |
| CRAN checks: |
cobenrich results |
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