RARtrials: Response-Adaptive Randomization in Clinical Trials

Some response-adaptive randomization methods commonly found in literature are included in this package. These methods include the randomized play-the-winner rule for binary endpoint (Wei and Durham (1978) <doi:10.2307/2286290>), the doubly adaptive biased coin design with minimal variance strategy for binary endpoint (Atkinson and Biswas (2013) <doi:10.1201/b16101>, Rosenberger and Lachin (2015) <doi:10.1002/9781118742112>) and maximal power strategy targeting Neyman allocation for binary endpoint (Tymofyeyev, Rosenberger, and Hu (2007) <doi:10.1198/016214506000000906>) and RSIHR allocation with each letter representing the first character of the names of the individuals who first proposed this rule (Youngsook and Hu (2010) <doi:10.1198/sbr.2009.0056>, Bello and Sabo (2016) <doi:10.1080/00949655.2015.1114116>), A-optimal Allocation for continuous endpoint (Sverdlov and Rosenberger (2013) <doi:10.1080/15598608.2013.783726>), Aa-optimal Allocation for continuous endpoint (Sverdlov and Rosenberger (2013) <doi:10.1080/15598608.2013.783726>), generalized RSIHR allocation for continuous endpoint (Atkinson and Biswas (2013) <doi:10.1201/b16101>), Bayesian response-adaptive randomization with a control group using the Thall \& Wathen method for binary and continuous endpoints (Thall and Wathen (2007) <doi:10.1016/j.ejca.2007.01.006>) and the forward-looking Gittins index rule for binary and continuous endpoints (Villar, Wason, and Bowden (2015) <doi:10.1111/biom.12337>, Williamson and Villar (2019) <doi:10.1111/biom.13119>).

Version:	0.0.2
Depends:	R (≥ 4.3), stats, pins
Imports:	Rdpack (≥ 0.7)
Suggests:	knitr, rmarkdown, testthat (≥ 3.0.0)
Published:	2025-04-03
DOI:	10.32614/CRAN.package.RARtrials
Author:	Chuyao Xu [aut, cre], Thomas Lumley [aut, ths], Alain Vandal [aut, ths], Sofia S. Villar [cph], Kyle J. Wathen [cph]
Maintainer:	Chuyao Xu <cxu870 at aucklanduni.ac.nz>
License:	GPL (≥ 3)
URL:	https://github.com/yayayaoyaoyao/RARtrials
NeedsCompilation:	no
Materials:	README
CRAN checks:	RARtrials results

Documentation:

Reference manual:	RARtrials.html , RARtrials.pdf
Vignettes:	Response-Adaptive randomization in Clinical Trials (source, R code)

Downloads:

Package source:	RARtrials_0.0.2.tar.gz
Windows binaries:	r-devel: RARtrials_0.0.2.zip, r-release: RARtrials_0.0.2.zip, r-oldrel: RARtrials_0.0.2.zip
macOS binaries:	r-release (arm64): RARtrials_0.0.2.tgz, r-oldrel (arm64): RARtrials_0.0.2.tgz, r-release (x86_64): RARtrials_0.0.2.tgz, r-oldrel (x86_64): RARtrials_0.0.2.tgz
Old sources:	RARtrials archive

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