Implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.
| Version: | 1.4 |
| Depends: | methods |
| Imports: | CompQuadForm, ape |
| Suggests: | multtest, rmarkdown, knitr |
| Published: | 2024-04-17 |
| DOI: | 10.32614/CRAN.package.POSTm |
| Author: | Caizhi Huang [aut], Jung-Ying Tzeng [aut], Shannon T. Holloway [aut, cre] |
| Maintainer: | Shannon T. Holloway <shannon.t.holloway at gmail.com> |
| License: | GPL-2 |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | POSTm results |
| Reference manual: | POSTm.html , POSTm.pdf |
| Vignettes: |
POSTm: $\text{\underline{P} (source, R code) |
| Package source: | POSTm_1.4.tar.gz |
| Windows binaries: | r-devel: POSTm_1.4.zip, r-release: POSTm_1.4.zip, r-oldrel: POSTm_1.4.zip |
| macOS binaries: | r-release (arm64): POSTm_1.4.tgz, r-oldrel (arm64): POSTm_1.4.tgz, r-release (x86_64): POSTm_1.4.tgz, r-oldrel (x86_64): POSTm_1.4.tgz |
| Old sources: | POSTm archive |
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