DrugSim2DR: Predict Drug Functional Similarity to Drug Repurposing

A systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. 'DrugSim2DR' first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

Version:	0.1.2
Depends:	R (≥ 3.6)
Imports:	igraph, stats, pheatmap, tidyr, reshape2, fastmatch
Suggests:	knitr, rmarkdown
Published:	2025-10-28
DOI:	10.32614/CRAN.package.DrugSim2DR
Author:	Junwei Han [aut, cre, cph], Ji Li [aut], Jiashuo Wu [aut]
Maintainer:	Junwei Han <hanjunwei1981 at 163.com>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
CRAN checks:	DrugSim2DR results

Documentation:

Reference manual:	DrugSim2DR.html , DrugSim2DR.pdf
Vignettes:	DrugSim2DR User Guide (source, R code)

Downloads:

Package source:	DrugSim2DR_0.1.2.tar.gz
Windows binaries:	r-devel: DrugSim2DR_0.1.1.zip, r-release: DrugSim2DR_0.1.2.zip, r-oldrel: DrugSim2DR_0.1.1.zip
macOS binaries:	r-release (arm64): DrugSim2DR_0.1.2.tgz, r-oldrel (arm64): DrugSim2DR_0.1.2.tgz, r-release (x86_64): DrugSim2DR_0.1.2.tgz, r-oldrel (x86_64): DrugSim2DR_0.1.2.tgz
Old sources:	DrugSim2DR archive

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